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This is less common when GLP-1 agonists are used alone

Probably due to the lack of complementary interacting residues, superimposing GIP or GLP-1 to GCG bound to GCGR shows that the aligned peptides reduced favorable contacts with GCGR compared to GCG by removing one hydrogen bond (Y10 P (GCG)/Y10 P (GIP)/V16 P (GLP-1)-Q142 1.40b (GCGR)) and pi-pi stacking (Y13 P (GCG)/A13 P (GIP)/Y19 P (GLP-1)-Y138 1.36b (GCGR)) and by repulsing the interaction between Y1 P (GIP) and I235 3.40b (GCGR)

Studies show that it can both improve the overall appearance of skin and may also be able to treat certain skin conditions

Napolitano et al., 2014

Concomitant use of apomorphine (brand names Apokyn, Onapgo)